HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2063280Generated: October 31, 2026
Ethyl Acetate → Ethyl 5-fluoro-1-(3-fluorobenzyl)-1H-indole-2-carboxylate
https://huagongshe.com/reaction/2063280
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 3-Fluorobenzyl chloride | HCID 9974 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | ethyl 5-fluoro-1H-indole-2-carboxylate | HCID 2727899 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Ethyl 5-fluoro-1-(3-fluorobenzyl)-1H-indole-2-carboxylate | HCID 57431514 | — |
Reaction Steps
A suspension of 1.035 g (5 mmol) of ethyl 5-fluoro-1H-indole-2-carboxylate, 0.865 g (6 mmol) of 3-fluorobenzyl chloride and 1.38 g (10 mmol) of potassium carbonate in 50 ml of dimethylformamide is stirred for 24 h at 60° C. The reaction mixture is subsequently cooled and poured into a mixture of ice-cold water and of ethyl acetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08288376B2 |
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| Source dataset | uspto-grants-2012_10 |
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| ORD ID | ord-a719559c0a8a40acbf2fe9638b40a889 |
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| Source note | uspto-grants-2012_10 |
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