4-Hydroxymethylpyridine → HCID 66811885, compound

HRID 2063291Notes

Reaction equation

HRID 2063291 reaction equation
[F:1][C:2]([F:18])([F:17])[C:3]1[N:8]=[C:7]2[CH:9]=[C:10]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[NH:11][C:6]2=[CH:5][CH:4]=1.[N:19]1[CH:24]=[CH:23][C:22]([CH2:25]O)=[CH:21][CH:20]=1>>[N:19]1[CH:24]=[CH:23][C:22]([CH2:25][N:11]2[C:6]3[C:7](=[N:8][C:3]([C:2]([F:1])([F:17])[F:18])=[CH:4][CH:5]=3)[CH:9]=[C:10]2[C:12]([O:14][CH2:15][CH3:16])=[O:13])=[CH:21][CH:20]=1

Participants

3

Reactant 2

HCID 114724-HydroxymethylpyridineHCID 66811603Ethyl 5-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine-2-carboxylate

Product 1

HCID 66811885HCID 66811885, compoundYield 65.3%

Procedure

According to a process similar to that described in Example 24.1, using 5 g (18.4 mmol) of ethyl 5-tri-fluoromethyl-1H-pyrrolo[3,2-b]pyridine-2-carboxylate (Example 23.3) and 3.04 g (27.6 mmol) of (pyridin-4-yl)methanol, 4.2 g of the expected compound are isolated.

Sources & evidence

ORD record
ord-38c5940ab7c04cabbd281ccb27895a63
Source dataset
uspto-grants-2012_10
Patent number
US08288376B2

Reaction notes

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