HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium formate → 2-azetidin-3-yloctahydro-6H-pyrido[1,2-a]pyrazin-6-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium formate | HCID 2723923 | — |
| Reactant | 2-[1-(diphenylmethyl)azetidin-3-yl]octahydro-6H-pyrido[1,2-a]pyrazin-6-one | HCID 16123294 | — |
| Catalyst | Palladium hydroxide | HCID 9942167 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-azetidin-3-yloctahydro-6H-pyrido[1,2-a]pyrazin-6-one | HCID 16123295 | 100% |
Reaction Conditions
| Temperature | 120 °C |
|---|
Reaction Steps
(+)-(2-[1-(Diphenylmethyl)azetidin-3-yl]octahydro-6H-pyrido[1,2-a]pyrazin-6-one (138 mg, 0.37 mmol) and ammonium formate (70 mg, 1.1 mmol) were dissolved in ethanol (3 mL). Palladium hydroxide on carbon (52 mg) was added and the reaction mixture was heated to 120° C. for 2 min using microwave single node heating. The catalyst was filtered off and the solvent was removed by evaporation. There was obtained 77 mg (100%) of the title compound. LCMS: m/z 210 (M+1)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08288370B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-a4e0391398ce417284ca8437b96f4eb7 |
| Source note | uspto-grants-2012_10 |