Ammonium formate → 2-azetidin-3-yloctahydro-6H-pyrido[1,2-a]pyrazin-6-one

HRID 2063307노트

반응식

HRID 2063307 반응식
C1(C(C2C=CC=CC=2)[N:8]2[CH2:11][CH:10]([N:12]3[CH2:17][CH2:16][N:15]4[C:18](=[O:22])[CH2:19][CH2:20][CH2:21][CH:14]4[CH2:13]3)[CH2:9]2)C=CC=CC=1.C([O-])=O.[NH4+]>C(O)C.[OH-].[OH-].[Pd+2]>[NH:8]1[CH2:9][CH:10]([N:12]2[CH2:17][CH2:16][N:15]3[C:18](=[O:22])[CH2:19][CH2:20][CH2:21][CH:14]3[CH2:13]2)[CH2:11]1

참가 물질

5

반응물 2

HCID 2723923Ammonium formateHCID 161232942-[1-(diphenylmethyl)azetidin-3-yl]octahydro-6H-pyrido[1,2-a]pyrazin-6-one

생성물 1

HCID 161232952-azetidin-3-yloctahydro-6H-pyrido[1,2-a]pyrazin-6-one수율 100%

시약·촉매·용매 2

HCID 9942167Palladium hydroxide촉매HCID 702Ethanol용매

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온도
120 °C

실험 절차

(+)-(2-[1-(Diphenylmethyl)azetidin-3-yl]octahydro-6H-pyrido[1,2-a]pyrazin-6-one (138 mg, 0.37 mmol) and ammonium formate (70 mg, 1.1 mmol) were dissolved in ethanol (3 mL). Palladium hydroxide on carbon (52 mg) was added and the reaction mixture was heated to 120° C. for 2 min using microwave single node heating. The catalyst was filtered off and the solvent was removed by evaporation. There was obtained 77 mg (100%) of the title compound. LCMS: m/z 210 (M+1)+.

후처리

  1. temperatureheating
  2. filtrationThe catalyst was filtered off
  3. customthe solvent was removed by evaporation

출처 및 근거

ORD 기록
ord-a4e0391398ce417284ca8437b96f4eb7
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08288370B2

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