反应详情

1-[1-(diphenylmethyl)azetidin-3-yl]-4-propionylpiperazine (0.22 g, 0.59 mmol) was dissolved in a mixture of ethanol (9 mL) and acetic acid (0.2 mL) and to the resultant solution was added palladium hydroxide on carbon (83 mg). The mixture was stirred under hydrogen (5 bar) at RT for 23 h and then the catalyst was filtered off by means of a phase separator column then washing with ethanol. The solvent was removed by evaporation and the residue was dissolved in methanol (1 mL). The solution was filtered through a cation exchange column (Isolate SCX-2, 10 g). The column was washed with THF and then the product was eluted with ammonia-saturated methanol. The solvent was removed by evaporation and there was obtained 0.13 g (100%) of the title compound as an oil. 1H NMR (500 MHz, CD3OD): 1.1 (t, 3H), 2.3-2.5 (m, 6H), 3.4 (m, 1H), 3.6 (m, 4H), 3.9-4.0 (m, 4H).

1. filtrationthe catalyst was filtered off by means of a phase separator column
2. washthen washing with ethanol
3. customThe solvent was removed by evaporation
4. dissolutionthe residue was dissolved in methanol (1 mL)
5. filtrationThe solution was filtered through a cation exchange column (Isolate SCX-2, 10 g)
6. washThe column was washed with THF
7. washthe product was eluted with ammonia-saturated methanol
8. customThe solvent was removed by evaporation