Methanol → HCID 16123185, compound

HRID 2063312Notes

Reaction equation

HRID 2063312 reaction equation
C1(C(C2C=CC=CC=2)[N:8]2[CH2:11][CH:10]([N:12]3[CH2:17][CH2:16][N:15]([C:18]([CH:20]4[CH2:24][CH2:23][CH2:22][O:21]4)=[O:19])[CH2:14][CH2:13]3)[CH2:9]2)C=CC=CC=1.CO>[OH-].[OH-].[Pd+2].C(O)(=O)C>[NH:8]1[CH2:11][CH:10]([N:12]2[CH2:13][CH2:14][N:15]([C:18]([CH:20]3[CH2:24][CH2:23][CH2:22][O:21]3)=[O:19])[CH2:16][CH2:17]2)[CH2:9]1

Participants

5

Reactant 2

HCID 887MethanolHCID 16123184HCID 16123184, compound

Product 1

HCID 16123185HCID 16123185, compound

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 176Acetic AcidSolvent

Procedure

Palladium hydroxide on carbon (0.15 g) was placed in a 5 mL tube and then a solution of 1-[1-(diphenylmethyl)azetidin-3-yl]-4-(tetrahydrofuran-2-ylcarbonyl)piperazine (0.66 g, 1.6 mmol), methanol (4 mL) and acetic acid (0.3 mL) was added. The mixture was stirred under hydrogen (1.6 bar) at RT for 60 h and then the catalyst was filtered off by means of Celite®. The solvent was removed by evaporation and the crude product was used in the next step without quantification. LCMS: m/z 240 (M+1)+.

Workup

  1. filtrationthe catalyst was filtered off by means of Celite®
  2. customThe solvent was removed by evaporation

Sources & evidence

ORD record
ord-fba59a7213b44033b1afefd2033591e1
Source dataset
uspto-grants-2012_10
Patent number
US08288370B2

Reaction notes

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