Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | tert-Butyl (2R)-2-{4-[(4-chlorophenyl)methyl]-4H-1,2,4-triazol-3-yl}pyrrolidine-1-carboxylate | HCID 53486874 | — |
| Solvent | O-Xylene | HCID 7237 | — |
| Product | HCID 57650371 | HCID 57650371 | 101.4% |
Reaction Steps
A mixture of Boc-protected triazole from example 3 (7.7 g, 21.221 mmol) and paraformaldehyde (3.23 g, 5 eq.) in 50 mL of o-xylene was heated at 125° C. for 3 h. After cooling, the mixture was filtered over a Celite-fritted funnel and washed with 10 mL of o-xylene. The filtrate was concentrated in vacuo to provide the desired intermediate as a foam (8.45 g, 100%+)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08288371B2 |
|---|
| Source dataset | uspto-grants-2012_10 |
|---|
| ORD ID | ord-912cd1016a4b49b49905fe507c602191 |
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| Source note | uspto-grants-2012_10 |
|---|
