HCID 57650585, compound → HCID 57650511, compound

HRID 2063477Notes

Reaction equation

HRID 2063477 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]([N:10]2[C:14]([CH3:15])=[N:13][N:12]=[C:11]2[C@H:16]2[CH2:20][CH2:19][CH2:18][N:17]2C(OC(C)(C)C)=O)[CH3:9])=[CH:4][CH:3]=1>C(O)(C(F)(F)F)=O.C(Cl)Cl>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]([N:10]2[C:11]([C@H:16]3[CH2:20][CH2:19][CH2:18][NH:17]3)=[N:12][N:13]=[C:14]2[CH3:15])[CH3:9])=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 57650585HCID 57650585, compound

Product 1

HCID 57650511HCID 57650511, compound

Reagents, catalysts & solvents 1

HCID 21863450Trifluoroacetic acid methylene chlorideSolvent

Procedure

A solution of the Boc-protected triazole product of Step C (1 g) in 40 ml of 40% TFA/DCM was stirred at room temperature for 4 h. The mixture was concentrated in vacuo and used directly as the TFA salt in the next step. MS: calculated: 290.13. Found (MH+): 291.3

Workup

  1. concentrationThe mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-a0a56f7e1f8144a393ab47782bd6b29c
Source dataset
uspto-grants-2012_10
Patent number
US08288371B2

Reaction notes

Loading…