反应详情

温度

140 °C

A mixture of product from step 2 (1.66 g, 6.58 mmol) and [1,4]Diazepane-1-carboxylic acid tert-butyl ester (4 g, 20 mmol) was heated via microwave to 140° C. for 1 h. After being cooled to rt, it was diluted with ethyl acetate, washed with saturated NaHCO3 and brine, dried over Na2SO4 and then purified by flash column chromatography on silica gel to give the desired product (0.8 g, 35%). MS (ES) m/z 358 (M+H+).

1. temperatureAfter being cooled to rt
2. washwashed with saturated NaHCO3 and brine
3. dry with materialdried over Na2SO4
4. custompurified by flash column chromatography on silica gel