反应详情

To a solution of 4-chloro-2-methyl-6-phenylpyrimidine (11 g, 0.0537 mol) in dioxane (100 ml) was added anhydrous hydrazine (2 g, 0.0625 mol) followed by potassium carbonate (11 g, 0.080 mol) and the reaction mixture was stirred at room temperature for 6 h. The reaction mixture was filtered and the filtrate was evaporated under reduced pressure. The residue was treated with 2M HCl in dioxane (100 ml) and the solid precipitated was filtered and washed with methanol (100 ml) and dried under suction to afford 10 g (60%) of the titled compound as a solid.

1. filtrationThe reaction mixture was filtered
2. customthe filtrate was evaporated under reduced pressure
3. additionThe residue was treated with 2M HCl in dioxane (100 ml)
4. customthe solid precipitated
5. filtrationwas filtered
6. washwashed with methanol (100 ml)
7. customdried under suction