4-Dimethylaminoacetophenone → (4-{1-[(6-Chloro-2-methoxy-pyrimidin-4-yl)hydrazono]-ethyl}-phenyl)-dimethylamine

HRID 2063606Notes

Reaction equation

HRID 2063606 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([O:8][CH3:9])[N:5]=[C:4]([NH:10][NH2:11])[CH:3]=1.[CH3:12][C:13]([C:15]1[CH:20]=[CH:19][C:18]([N:21]([CH3:23])[CH3:22])=[CH:17][CH:16]=1)=O>C(O)C>[Cl:1][C:2]1[N:7]=[C:6]([O:8][CH3:9])[N:5]=[C:4]([NH:10][N:11]=[C:13]([C:15]2[CH:20]=[CH:19][C:18]([N:21]([CH3:23])[CH3:22])=[CH:17][CH:16]=2)[CH3:12])[CH:3]=1

Participants

4

Reactant 2

HCID 750374-DimethylaminoacetophenoneHCID 55281294(6-Chloro-2-methoxy-pyrimidin-4-yl)hydrazine

Product 1

HCID 72577512(4-{1-[(6-Chloro-2-methoxy-pyrimidin-4-yl)hydrazono]-ethyl}-phenyl)-dimethylamine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The title compound was prepared from (6-chloro-2-methoxy-pyrimidin-4-yl)hydrazine (414 mg, 2.4 mmol) and 4-dimethylaminoacetophenone (387 mg, 2.4 mmol) in ethanol (10 mL) by a procedure similar to Example 1, step 4 yielding 305 mg (40%).

Sources & evidence

ORD record
ord-d19008241f214c78b5ba45f3348a6f47
Source dataset
uspto-grants-2012_10
Patent number
US08288398B2

Reaction notes

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