1-((4-methoxyphenyl)methyl)-1H-1,2,4-triazol-3-amine → 5-[1-(4-Methoxy-benzyl)-1H-[1,2,4]triazol-3-ylamino]-2-(4-methyl-imidazol-1-yl)-benzonitrile

HRID 2063637Notes

Reaction equation

HRID 2063637 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]([N:10]2[CH:14]=[C:13]([CH3:15])[N:12]=[CH:11]2)=[C:6]([CH:9]=1)[C:7]#[N:8].[CH3:16][O:17][C:18]1[CH:30]=[CH:29][C:21]([CH2:22][N:23]2[CH:27]=[N:26][C:25]([NH2:28])=[N:24]2)=[CH:20][CH:19]=1>>[CH3:16][O:17][C:18]1[CH:19]=[CH:20][C:21]([CH2:22][N:23]2[CH:27]=[N:26][C:25]([NH:28][C:2]3[CH:3]=[CH:4][C:5]([N:10]4[CH:14]=[C:13]([CH3:15])[N:12]=[CH:11]4)=[C:6]([CH:9]=3)[C:7]#[N:8])=[N:24]2)=[CH:29][CH:30]=1

Participants

3

Reactant 2

HCID 609114561-((4-methoxyphenyl)methyl)-1H-1,2,4-triazol-3-amineHCID 669615175-bromo-2-(4-methyl-1H-imidazol-1-yl)benzonitrile

Product 1

HCID 593240615-[1-(4-Methoxy-benzyl)-1H-[1,2,4]triazol-3-ylamino]-2-(4-methyl-imidazol-1-yl)-benzonitrile

Procedure

Prepared in analogy to example 1b) starting with 5-bromo-2-(4-methyl-imidazol-1-yl)-benzonitrile and 1-(4-methoxy-benzyl)-1H-[1,2,4]triazol-3-ylamine. The title compound was obtained as a colorless oil (Yield=34%). MS ISP (m/e): 386.2 (100) [(M+H)+].

Workup

  1. customPrepared in analogy to example 1b)

Sources & evidence

ORD record
ord-d24ec868200146fe979963cb226c8846
Source dataset
uspto-grants-2012_10
Patent number
US08288403B2

Reaction notes

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