4-[(3-amino-1H-1,2,4-triazol-1-yl)methyl]benzonitrile → 5-[1-(4-Cyano-benzyl)-1H-[1,2,4]triazol-3-ylamino]-2-(4-methyl-imidazol-1-yl)-benzonitrile

HRID 2063641Notes

Reaction equation

HRID 2063641 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]([N:10]2[CH:14]=[C:13]([CH3:15])[N:12]=[CH:11]2)=[C:6]([CH:9]=1)[C:7]#[N:8].[NH2:16][C:17]1[N:21]=[CH:20][N:19]([CH2:22][C:23]2[CH:30]=[CH:29][C:26]([C:27]#[N:28])=[CH:25][CH:24]=2)[N:18]=1>>[C:27]([C:26]1[CH:25]=[CH:24][C:23]([CH2:22][N:19]2[CH:20]=[N:21][C:17]([NH:16][C:2]3[CH:3]=[CH:4][C:5]([N:10]4[CH:14]=[C:13]([CH3:15])[N:12]=[CH:11]4)=[C:6]([CH:9]=3)[C:7]#[N:8])=[N:18]2)=[CH:30][CH:29]=1)#[N:28]

Participants

3

Reactant 2

HCID 609117294-[(3-amino-1H-1,2,4-triazol-1-yl)methyl]benzonitrileHCID 669615175-bromo-2-(4-methyl-1H-imidazol-1-yl)benzonitrile

Product 1

HCID 462160905-[1-(4-Cyano-benzyl)-1H-[1,2,4]triazol-3-ylamino]-2-(4-methyl-imidazol-1-yl)-benzonitrile

Procedure

Prepared in analogy to example 1b) starting with 5-bromo-2-(4-methyl-imidazol-1-yl)-benzonitrile and 4-(3-amino-[1,2,4]triazol-1-ylmethyl)-benzonitrile. The title compound was obtained as an off-white solid (Yield=36%). MS ISP (m/e): 381.2 (100) [(M+H)+].

Workup

  1. customPrepared in analogy to example 1b)

Sources & evidence

ORD record
ord-8c9e69b76d684b83b3bca0e56c331d78
Source dataset
uspto-grants-2012_10
Patent number
US08288403B2

Reaction notes

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