1-phenyl-1H-1,2,4-triazol-3-amine → 2-(4-Methyl-imidazol-1-yl)-5-(1-phenyl-1H-[1,2,4]triazol-3-ylamino)-benzonitrile

HRID 2063652Notes

Reaction equation

HRID 2063652 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]([N:10]2[CH:14]=[C:13]([CH3:15])[N:12]=[CH:11]2)=[C:6]([CH:9]=1)[C:7]#[N:8].[C:16]1([N:22]2[CH:26]=[N:25][C:24]([NH2:27])=[N:23]2)[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[CH3:15][C:13]1[N:12]=[CH:11][N:10]([C:5]2[CH:4]=[CH:3][C:2]([NH:27][C:24]3[N:25]=[CH:26][N:22]([C:16]4[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=4)[N:23]=3)=[CH:9][C:6]=2[C:7]#[N:8])[CH:14]=1

Participants

3

Reactant 2

HCID 218217441-phenyl-1H-1,2,4-triazol-3-amineHCID 669615175-bromo-2-(4-methyl-1H-imidazol-1-yl)benzonitrile

Product 1

HCID 462142412-(4-Methyl-imidazol-1-yl)-5-(1-phenyl-1H-[1,2,4]triazol-3-ylamino)-benzonitrile

Procedure

Prepared in analogy to example 1b) starting with 5-bromo-2-(4-methyl-imidazol-1-yl)-benzonitrile and 1-phenyl-1H-[1,2,4]triazol-3-ylamine. The title compound was obtained as a brownish solid (Yield=64%). MS ISP (m/e): 340.4 (100) [(M+H)+].

Workup

  1. customPrepared in analogy to example 1b)

Sources & evidence

ORD record
ord-5d20d1131d9b4c5ba1b7b76ba4f9429b
Source dataset
uspto-grants-2012_10
Patent number
US08288403B2

Reaction notes

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