2-(Trifluoromethyl)aniline → 1-(2-trifluoromethyl-phenyl)-1H-[1,2,4]triazol-3-ylamine

HRID 2063653Notes

Reaction equation

HRID 2063653 reaction equation
C1([C:7]2O[N:10]=[C:9]([NH2:12])[N:8]=2)C=CC=CC=1.[NH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[C:20]([F:23])([F:22])[F:21]>>[F:23][C:20]([F:21])([F:22])[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=1[N:13]1[CH:7]=[N:8][C:9]([NH2:12])=[N:10]1

Participants

3

Reactant 2

HCID 69222-(Trifluoromethyl)anilineHCID 23054465-Phenyl-1,2,4-oxadiazol-3-amine

Product 1

HCID 623140051-(2-trifluoromethyl-phenyl)-1H-[1,2,4]triazol-3-ylamineYield 94%

Procedure

Prepared in analogy to example 18a), starting with 5-phenyl-[1,2,4]oxadiazol-3-ylamine and 2-aminobenzotrifluoride. The title compound was obtained as brownish solid in a yield of 94%. MS ISP (m/e): 229.2 (64) [(M+H)+].

Workup

  1. customPrepared in analogy to example 18a),

Sources & evidence

ORD record
ord-8bf32df4eb42479c8ab6b17b8ffe72e6
Source dataset
uspto-grants-2012_10
Patent number
US08288403B2

Reaction notes

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