5-bromo-2-(4-methyl-1H-imidazol-1-yl)benzonitrile → 2-(4-Methyl-imidazol-1-yl)-5-[1-(3,4,5-trifluoro-benzyl)-1H-pyrazol-3-ylamino]-benzonitrile

HRID 2063667Notes

Reaction equation

HRID 2063667 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]([N:10]2[CH:14]=[C:13]([CH3:15])[N:12]=[CH:11]2)=[C:6]([CH:9]=1)[C:7]#[N:8].[F:16][C:17]1[CH:18]=[C:19]([CH:27]=[C:28]([F:31])[C:29]=1[F:30])[CH2:20][N:21]1[CH:25]=[CH:24][C:23]([NH2:26])=[N:22]1>>[CH3:15][C:13]1[N:12]=[CH:11][N:10]([C:5]2[CH:4]=[CH:3][C:2]([NH:26][C:23]3[CH:24]=[CH:25][N:21]([CH2:20][C:19]4[CH:18]=[C:17]([F:16])[C:29]([F:30])=[C:28]([F:31])[CH:27]=4)[N:22]=3)=[CH:9][C:6]=2[C:7]#[N:8])[CH:14]=1

Participants

3

Reactant 2

HCID 669615175-bromo-2-(4-methyl-1H-imidazol-1-yl)benzonitrileHCID 673429711-(3,4,5-Trifluoro-benzyl)-1H-pyrazol-3-ylamine

Product 1

HCID 462166002-(4-Methyl-imidazol-1-yl)-5-[1-(3,4,5-trifluoro-benzyl)-1H-pyrazol-3-ylamino]-benzonitrile

Procedure

Prepared in analogy to example 1b) starting with 5-bromo-2-(4-methyl-imidazol-1-yl)-benzonitrile and 1-(3,4,5-trifluoro-benzyl)-1H-pyrazol-3-ylamine. The title compound was obtained as a white solid (Yield=56%). MS ISP (m/e): 409.3 (100) [(M+H)+].

Workup

  1. customPrepared in analogy to example 1b)

Sources & evidence

ORD record
ord-0612cbe31e29465b90634b557c641e36
Source dataset
uspto-grants-2012_10
Patent number
US08288403B2

Reaction notes

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