Hydrochloric Acid → HCID 86641714, compound

HRID 2063689Notes

Reaction equation

HRID 2063689 reaction equation
C([O:3][C:4]([C:6]1[N:7]=[C:8]([NH:11][C:12]2[CH:17]=[CH:16][C:15]([N:18]3[CH:22]=[C:21]([CH3:23])[N:20]=[CH:19]3)=[C:14]([O:24][CH3:25])[CH:13]=2)[S:9][CH:10]=1)=[O:5])C.[OH-].[K+].Cl>C(O)C>[CH3:25][O:24][C:14]1[CH:13]=[C:12]([NH:11][C:8]2[S:9][CH:10]=[C:6]([C:4]([OH:5])=[O:3])[N:7]=2)[CH:17]=[CH:16][C:15]=1[N:18]1[CH:22]=[C:21]([CH3:23])[N:20]=[CH:19]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 59324073HCID 59324073, compound

Product 1

HCID 86641714HCID 86641714, compoundYield 232.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
90 °C

Procedure

A mixture of 2-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenylamino]-thiazole-4-carboxylic acid ethyl ester (210 mg, 0.586 mmol), KOH (3M in water, 1172 1, 3.52 mmol) and ethanol (3 ml) was heated to 90° C. for 12 h and then cooled to 0° C. An aqueous HCl solution (1 N) was added until pH7. The solvents were evaporated, toluene was added to the residue and evaporated again to yield the title compound as light brown solid (450 mg (purity 43%), 100%) .

Workup

  1. temperaturecooled to 0° C
  2. customThe solvents were evaporated
  3. additiontoluene was added to the residue
  4. customevaporated again

Sources & evidence

ORD record
ord-333e611022a240629dca47f31abe7ee0
Source dataset
uspto-grants-2012_10
Patent number
US08288403B2

Reaction notes

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