1-(4-bromo-2-methoxyphenyl)-4-methyl-1H-imidazole → [3-Methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-[1-(3,4,5-trifluoro-benzyl)-1H-[1,2,4]triazol-3-yl]-amine

HRID 2063701Notes

Reaction equation

HRID 2063701 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:12]=[C:11]([CH3:13])[N:10]=[CH:9]2)=[C:4]([O:14][CH3:15])[CH:3]=1.[F:16][C:17]1[CH:18]=[C:19]([CH:27]=[C:28]([F:31])[C:29]=1[F:30])[CH2:20][N:21]1[CH:25]=[N:24][C:23]([NH2:26])=[N:22]1>>[CH3:15][O:14][C:4]1[CH:3]=[C:2]([NH:26][C:23]2[N:24]=[CH:25][N:21]([CH2:20][C:19]3[CH:27]=[C:28]([F:31])[C:29]([F:30])=[C:17]([F:16])[CH:18]=3)[N:22]=2)[CH:7]=[CH:6][C:5]=1[N:8]1[CH:12]=[C:11]([CH3:13])[N:10]=[CH:9]1

Participants

3

Reactant 2

HCID 534156611-(4-bromo-2-methoxyphenyl)-4-methyl-1H-imidazoleHCID 67343001HCID 67343001, compound

Product 1

HCID 46216605[3-Methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-[1-(3,4,5-trifluoro-benzyl)-1H-[1,2,4]triazol-3-yl]-amine

Procedure

Prepared in analogy to example 1b) starting with 1-(4-bromo-2-methoxy-phenyl)-4-methyl-1H-imidazole (WO2009076352) and 1-(3,4,5-trifluoro-benzyl)-1H-[1,2,4]triazol-3-ylamine from example 17a). The title compound was obtained as a colorless foam (Yield=49%). MS ISP (m/e): 415.2 (100) [(M+H)+].

Workup

  1. customPrepared in analogy to example 1b)

Sources & evidence

ORD record
ord-a836b534da554deabef8bea8b67b6c29
Source dataset
uspto-grants-2012_10
Patent number
US08288403B2

Reaction notes

Loading…