Hydrochloric Acid → 4-[2-(9-Benzenesulfonyl-1,3,4,9-tetrahydro-beta-carbolin-2-yl)-1-hydroxyethyl]cyclohexanone

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Reaction Steps

2 M hydrochloric acid (30 ml) was added to a solution of the product from stage 4 (748 mg, 1.50 mmol) in tetrahydrofuran (30 ml) and the mixture was stirred at room temperature for 16 h. The mixture was rendered alkaline with 4 M sodium hydroxide solution and extracted with ethyl acetate (3×35 ml). The combined organic phases were dried with sodium sulfate and concentrated i. vac.

Provenance & Evidence