反应详情

2 M hydrochloric acid was added to a solution of 1-(1,4-dioxaspiro[4.5]dec-8-yl)-2-phenoxyethanol (1.25 g, 4.5 mmol) in acetone (30 ml) and the mixture was stirred at room temperature for 48 h. The acetone was removed in vacuo, the pH of the aqueous residue was rendered alkaline with 2 M sodium hydroxide solution and the aqueous residue was extracted with methylene chloride (4×20 ml). The combined organic phases were dried with sodium sulfate and concentrated in vacuo.

1. customThe acetone was removed in vacuo
2. extractionthe aqueous residue was extracted with methylene chloride (4×20 ml)
3. dry with materialThe combined organic phases were dried with sodium sulfate
4. concentrationconcentrated in vacuo