Dimethylamine → HCID 59262855, compound

HRID 2063774Notes

Reaction equation

HRID 2063774 reaction equation
CS[C:3]1[S:7][C:6]([C:8]#[N:9])=[C:5]2[CH2:10][CH2:11][CH2:12][C:13](=[O:14])[C:4]=12.[CH3:15][NH:16][CH3:17]>C1COCC1>[CH3:15][N:16]([CH3:17])[C:3]1[S:7][C:6]([C:8]#[N:9])=[C:5]2[CH2:10][CH2:11][CH2:12][C:13](=[O:14])[C:4]=12

Participants

4

Reactant 2

HCID 674DimethylamineHCID 27787593-(Methylsulfanyl)-4-oxo-4,5,6,7-tetrahydro-2-benzothiophene-1-carbonitrile

Product 1

HCID 59262855HCID 59262855, compoundYield 45%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 3-methylsulfanyl-4-oxo-4,5,6,7-tetrahydro-benzo[c]thiophene-1-carbonitrile (0.446 g) and dimethylamine (excess) in THF were heated in a sealed tube at 80° C. for 10 days. Aqueous work up and chromatographic purification afforded 0.2 g of 3-dimethylamino-4-oxo-4,5,6,7-tetrahydro-benzo[c]thiophene-1-carbonitrile (45%).

Workup

  1. customAqueous work up and chromatographic purification

Sources & evidence

ORD record
ord-9b765534b6724fe9ac67c1c23000f976
Source dataset
uspto-grants-2012_10
Patent number
US08288400B2

Reaction notes

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