HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → (5,6-Dihydro-benzo[h]quinazolin-2-yl)-phenyl-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 2-dimethylaminomethylene-3,4-dihydro-2H-naphthalen-1-one | HCID 54406509 | — |
| Reactant | HCID 178418923 | HCID 178418923 | — |
| Product | (5,6-Dihydro-benzo[h]quinazolin-2-yl)-phenyl-amine | HCID 67406319 | — |
Reaction Steps
A solution of 2-dimethylaminomethylene-3,4-dihydro-2H-naphthalen-1-one 100 mg in 5 ml DMF and 3 eq. of N-phenyl-guanidine was stirred at 110° C. for overnight, the product was purified by directly injecting the DMF reaction solution into prep HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08288400B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-a566eeb1961d43f1992a4ef4934d4da0 |
| Source note | uspto-grants-2012_10 |