Dimethylformamide → (5,6-Dihydro-benzo[h]quinazolin-2-yl)-phenyl-amine

HRID 2063776Notes

Reaction equation

HRID 2063776 reaction equation
C[N:2]([CH:4]=[C:5]1[CH2:14][CH2:13][C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]1=O)[CH3:3].[C:16]1([NH:22]C(N)=N)[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.C[N:27](C=O)C>>[N:27]1[C:6]2[C:7]3[CH:8]=[CH:9][CH:10]=[CH:11][C:12]=3[CH2:13][CH2:14][C:5]=2[CH:4]=[N:2][C:3]=1[NH:22][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

4

Reactant 3

HCID 6228DimethylformamideHCID 544065092-dimethylaminomethylene-3,4-dihydro-2H-naphthalen-1-oneHCID 178418923HCID 178418923, compound

Product 1

HCID 67406319(5,6-Dihydro-benzo[h]quinazolin-2-yl)-phenyl-amine

Procedure

A solution of 2-dimethylaminomethylene-3,4-dihydro-2H-naphthalen-1-one 100 mg in 5 ml DMF and 3 eq. of N-phenyl-guanidine was stirred at 110° C. for overnight, the product was purified by directly injecting the DMF reaction solution into prep HPLC.

Workup

  1. customthe product was purified
  2. customthe DMF reaction solution into prep HPLC

Sources & evidence

ORD record
ord-a566eeb1961d43f1992a4ef4934d4da0
Source dataset
uspto-grants-2012_10
Patent number
US08288400B2

Reaction notes

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