1-(4-Methoxyphenyl)piperazine → 1-(4-Methoxyphenyl)-4-[2,4,6,7-tetramethyl-2,3-dihydro-1-benzofuran-5-yl]piperazine

HRID 2063841Notes

Reaction equation

HRID 2063841 reaction equation
Br[C:2]1[C:3]([CH3:14])=[C:4]([CH3:13])[C:5]2[O:9][CH:8]([CH3:10])[CH2:7][C:6]=2[C:11]=1[CH3:12].[CH3:15][O:16][C:17]1[CH:22]=[CH:21][C:20]([N:23]2[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]2)=[CH:19][CH:18]=1>>[CH3:15][O:16][C:17]1[CH:18]=[CH:19][C:20]([N:23]2[CH2:28][CH2:27][N:26]([C:2]3[C:3]([CH3:14])=[C:4]([CH3:13])[C:5]4[O:9][CH:8]([CH3:10])[CH2:7][C:6]=4[C:11]=3[CH3:12])[CH2:25][CH2:24]2)=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 2697221-(4-Methoxyphenyl)piperazineHCID 667602875-Bromo-2,4,6,7-tetramethyl-2,3-dihydrobenzofuran

Product 1

HCID 594850161-(4-Methoxyphenyl)-4-[2,4,6,7-tetramethyl-2,3-dihydro-1-benzofuran-5-yl]piperazineYield 39%

Procedure

By using 5-bromo-2,4,6,7-tetramethyl-2,3-dihydro-1-benzofuran (4.02 g, 15.8 mmol) synthesized in Reference example 53 and 1-(4-methoxyphenyl)piperazine (6.08 g, 31.6 mmol), the reaction was carried out in the same manner as Example 1 to obtain the title compound 2.25 g (yield 39%).

Sources & evidence

ORD record
ord-72129f4e52204fec9be0d6243d76612b
Source dataset
uspto-grants-2012_10
Patent number
US08288390B2

Reaction notes

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