HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-Methoxyphenyl)piperazine → 1-(4-Methoxyphenyl)-4-[2,4,6,7-tetramethyl-2,3-dihydro-1-benzofuran-5-yl]piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-Methoxyphenyl)piperazine | HCID 269722 | — |
| Reactant | 5-Bromo-2,4,6,7-tetramethyl-2,3-dihydrobenzofuran | HCID 66760287 | — |
| Product | 1-(4-Methoxyphenyl)-4-[2,4,6,7-tetramethyl-2,3-dihydro-1-benzofuran-5-yl]piperazine | HCID 59485016 | 39% |
Reaction Steps
By using 5-bromo-2,4,6,7-tetramethyl-2,3-dihydro-1-benzofuran (4.02 g, 15.8 mmol) synthesized in Reference example 53 and 1-(4-methoxyphenyl)piperazine (6.08 g, 31.6 mmol), the reaction was carried out in the same manner as Example 1 to obtain the title compound 2.25 g (yield 39%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08288390B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-72129f4e52204fec9be0d6243d76612b |
| Source note | uspto-grants-2012_10 |