Dichloromethane → HCID 68640380, compound

HRID 2063931Notes

Reaction equation

HRID 2063931 reaction equation
[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[N:4]=[C:3]1[CH:11]1[CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13][CH2:12]1.C(OCC)(=O)C.C(Cl)[Cl:31]>>[Cl-:31].[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[N:4]=[C:3]1[CH:11]1[CH2:16][CH2:15][NH2+:14][CH2:13][CH2:12]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 8857Ethyl AcetateHCID 68783444HCID 68783444, compound

Product 1

HCID 68640380HCID 68640380, compound

Procedure

The above piperidine (50.0 mg, 0.160 mmol) was dissolved in DCM (5 mL) and ethyl acetate (5 mL) and cooled to 0° C. Hydrogen chloride gas was bubbled through the solution for 30 seconds, which was stirred for 30 minutes before warming to ambient temperature. The reaction mixture was concentrated to dryness to afford 4-(1-methyl-1H-benzimidazol-2-yl)piperidinium chloride.

Workup

  1. customHydrogen chloride gas was bubbled through the solution for 30 seconds
  2. concentrationThe reaction mixture was concentrated to dryness

Sources & evidence

ORD record
ord-18406b616fc6417eac24f0835d6632a7
Source dataset
uspto-grants-2012_10
Patent number
US08288409B2

Reaction notes

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