Oxalyl chloride → 2,2-Dimethyl-3-acetyloxypropionyl chloride

HRID 2063943Notes

Reaction equation

HRID 2063943 reaction equation
[CH3:1][C:2]([CH3:11])([CH2:6][O:7][C:8](=[O:10])[CH3:9])[C:3](O)=[O:4].C(Cl)(=O)C([Cl:15])=O>C1C=CC=CC=1>[CH3:1][C:2]([CH3:11])([CH2:6][O:7][C:8](=[O:10])[CH3:9])[C:3]([Cl:15])=[O:4]

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 131926213-(Acetyloxy)-2,2-dimethylpropanoic acid2×

Product 1

HCID 111946632,2-Dimethyl-3-acetyloxypropionyl chloride

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Conditions

Temperature
0 °C

Procedure

The product of Step A, 2,2-dimethyl-3-acetyloxypropionic acid (11.76 g, 80 mmol) was dissolved in benzene (100 mL), and the reaction solution was cooled to 0° C., and then oxalyl chloride (15.0 g, 120 mmol) was slowly added dropwise. After 3 hours, the solvent was removed in vacuo, and the reaction mixture was distilled in vacuo to give the title compound.

Workup

  1. customthe solvent was removed in vacuo
  2. distillationthe reaction mixture was distilled in vacuo

Sources & evidence

ORD record
ord-f3ca9d4646904e8aa7c79f1ce0a8bd1c
Source dataset
uspto-grants-2012_10
Patent number
US08288386B2

Reaction notes

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