Hydrochloric Acid → HCID 57423905, compound

HRID 2064054Notes

Reaction equation

HRID 2064054 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:9][C:8](=[O:10])[N:7]([CH:11]3[CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13][CH2:12]3)[C:6]=2[CH:24]=1.Cl>C(O)C>[ClH:1].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:9][C:8](=[O:10])[N:7]([CH:11]3[CH2:12][CH2:13][NH:14][CH2:15][CH2:16]3)[C:6]=2[CH:24]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59863032HCID 59863032, compound

Product 1

HCID 57423905HCID 57423905, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1,1-Dimethylethyl 4-(6-chloro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidine-carboxylate D29 (5.7 g) was dissolved in ethanol (20 mL) and HCl (4M in 1,4-dioxane, 20 mL) was added at room temperature. The mixture was stirred at room temperature for 1 h. then filtered washing with ether to give the title compound, 4.0 g.

Workup

  1. filtrationthen filtered
  2. washwashing with ether

Sources & evidence

ORD record
ord-afe80b97b6cb445094a891b5854dd125
Source dataset
uspto-grants-2012_10
Patent number
US08288413B2

Reaction notes

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