Hydrochloric Acid → HCID 57423926, compound

HRID 2064068Notes

Reaction equation

HRID 2064068 reaction equation
[O:1]=[C:2]1[N:6]([CH:7]2[CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9][CH2:8]2)[C:5]2[CH:20]=[C:21]([O:24][C:25]([F:28])([F:27])[F:26])[CH:22]=[CH:23][C:4]=2[NH:3]1.[ClH:29]>CO.C(O)C>[ClH:29].[NH:10]1[CH2:11][CH2:12][CH:7]([N:6]2[C:5]3[CH:20]=[C:21]([O:24][C:25]([F:27])([F:26])[F:28])[CH:22]=[CH:23][C:4]=3[NH:3][C:2]2=[O:1])[CH2:8][CH2:9]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 66741150HCID 66741150, compound

Product 1

HCID 57423926HCID 57423926, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 887MethanolSolvent

Procedure

A solution of 1,1-dimethylethyl 4-{2-oxo-6-[(trifluoromethyl)oxy]-2,3-dihydro-1H-benzimidazol-1-yl}-1-piperidinecarboxylate (D31) (1.54 g) in methanol (20 mL) was treated with a saturated solution of hydrogen chloride in ethanol (10 mL). The mixture was stirred for 1 hour when the solvent was removed to give the title compound as a white solid (1.28 g).

Workup

  1. customwas removed

Sources & evidence

ORD record
ord-78188e02c3bf4df690129b882ef4957a
Source dataset
uspto-grants-2012_10
Patent number
US08288413B2

Reaction notes

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