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HRID 2064076作成日：2026年10月25日
Diisopropylethylamine → 1,1-Dimethylethyl 4-({5-[(1-methylethyl)oxy]-2-nitrophenyl}amino)-1-piperidinecarboxylate
https://huagongshe.com/reaction/2064076
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 4-Amino-1-Boc-piperidine | HCID 1268291 | — |
| 反応物 | 2-Fluoro-4-isopropoxy-1-nitrobenzene | HCID 13538652 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 1,1-Dimethylethyl 4-({5-[(1-methylethyl)oxy]-2-nitrophenyl}amino)-1-piperidinecarboxylate | HCID 57423916 | 97.5% |
反応手順
A solution of 2-fluoro-4-[(1-methylethyl)oxy]-1-nitrobenzene (D46, 276 mg, 1.39 mmol) in dimethylformamide (10 ml) was treated with 1,1-dimethylethyl 4-amino-1-piperidinecarboxylate (278 mg, 1.39 mmol) and diisopropylethylamine (0.241 ml, 1.39 mmol) and stirred at approx. 80° C. for 17 hrs. The mixture was concentrated under vacuum and the residue treated with water and extracted with a mixture of ethyl acetate/diethyl ether (×2). The combined extract was dried and concentrated under vacuum to afford the title compound as a yellow oil/solid (514 mg, 97%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US08288413B2 |
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| 出典データセット | uspto-grants-2012_10 |
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| ORD ID | ord-6d52a82122ed402eb58d2a769754cdd8 |
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| 出典メモ | uspto-grants-2012_10 |
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