反应详情

温度

80 °C

A solution of 2-fluoro-4-[(1-methylethyl)oxy]-1-nitrobenzene (D46, 276 mg, 1.39 mmol) in dimethylformamide (10 ml) was treated with 1,1-dimethylethyl 4-amino-1-piperidinecarboxylate (278 mg, 1.39 mmol) and diisopropylethylamine (0.241 ml, 1.39 mmol) and stirred at approx. 80° C. for 17 hrs. The mixture was concentrated under vacuum and the residue treated with water and extracted with a mixture of ethyl acetate/diethyl ether (×2). The combined extract was dried and concentrated under vacuum to afford the title compound as a yellow oil/solid (514 mg, 97%).

1. concentrationThe mixture was concentrated under vacuum
2. additionthe residue treated with water
3. extractionextracted with a mixture of ethyl acetate/diethyl ether (×2)
4. extractionThe combined extract
5. customwas dried
6. concentrationconcentrated under vacuum