反应详情

温度

45 °C

A partial solution of 1,1-dimethylethyl 4-({5-[(1-methylethyl)oxy]-2-nitrophenyl}amino)-1-piperidinecarboxylate (D47, 514 mg, 1.35 mmol) in ethanol (20 ml) was treated with Raney Nickel followed by dropwise addition of a solution of hydrazine hydrate (0675 ml, 13.5 mmol) in ethanol. The mixture was heated at 45° C. for 2 hrs, then the Raney Nickel was filtered off washing with ethanol and the filtrate concentrated under vacuum to afford the title compound as a violet coloured oil (470 mg, 99%).

1. filtrationthe Raney Nickel was filtered off
2. washwashing with ethanol
3. concentrationthe filtrate concentrated under vacuum