Hydrochloric Acid → HCID 57423922, compound

HRID 2064082Notes

Reaction equation

HRID 2064082 reaction equation
[F:1][CH:2]([F:27])[O:3][C:4]1[CH:5]=[CH:6][C:7]2[NH:11][C:10](=[O:12])[N:9]([CH:13]3[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][CH2:14]3)[C:8]=2[CH:26]=1.[ClH:28]>CO.C(O)C>[ClH:28].[F:27][CH:2]([F:1])[O:3][C:4]1[CH:5]=[CH:6][C:7]2[NH:11][C:10](=[O:12])[N:9]([CH:13]3[CH2:14][CH2:15][NH:16][CH2:17][CH2:18]3)[C:8]=2[CH:26]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 57423921HCID 57423921, compound

Product 1

HCID 57423922HCID 57423922, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 887MethanolSolvent

Procedure

A solution of 1,1-dimethylethyl 4-{6-[(difluoromethyl)oxy]-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl}-1-piperidinecarboxylate (D53, 0.54 g) in methanol (5 ml) was treated with a saturated solution of hydrogen chloride in ethanol (5 ml). The mixture was stirred for 1 hour when the solvent was removed to give the title compound as a white solid (0.45 g). Mass Spectrum 284 M+H+

Workup

  1. customwas removed

Sources & evidence

ORD record
ord-231c0727d97140b5ad3731d3e66f1935
Source dataset
uspto-grants-2012_10
Patent number
US08288413B2

Reaction notes

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