反应详情

A stirred solution of N-{2-nitro-5-[(2,2,2-trifluoroethyl)oxy]phenyl}-1-(tetrahydro-2H-pyran-4-yl)-4-piperidinamine (D56, 210 mg, 0.52 mmol) in ethanol (15 ml) at room temperature under argon was treated with Raney Nickel (20 mg) followed by dropwise addition of hydrazine hydrate (0.16 ml, 5.0 mmol). The mixture was maintained at room temperature for 1 hr, then filtered through Kieselguhr and the filtrate concentrated under vacuum to leave the title compound as a pale grey solid (190 mg, 98%).

1. filtrationfiltered through Kieselguhr
2. concentrationthe filtrate concentrated under vacuum