Hydrochloric Acid → Hydrochloric Acid

Participants

Reaction Steps

1,1-Dimethylethyl 4-(6-chloro-5-fluoro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinecarboxylate (D4) (0.460 mmol, 170 mg) was dissolved in dichloromethane-diethyl ether, and HCl (5 ml of a 4M solution in 1,4-dioxane) was added at room temperature; the mixture was shaken at room temperature overnight. Solvent was evaporated to afford the title compound, mono hydrochloride salt, complete conversion, M++H=270.

Provenance & Evidence