Hydrochloric Acid → Hydrochloric Acid

HRID 2064123Notes

Reaction equation

HRID 2064123 reaction equation
[Cl:1][C:2]1[C:3]([F:25])=[CH:4][C:5]2[NH:9][C:8](=[O:10])[N:7]([CH:11]3[CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13][CH2:12]3)[C:6]=2[CH:24]=1.[ClH:26]>ClCCl.C(OCC)C.O1CCOCC1>[ClH:1].[Cl:1][C:2]1[C:3]([F:25])=[CH:4][C:5]2[NH:9][C:8](=[O:10])[N:7]([CH:11]3[CH2:12][CH2:13][NH:14][CH2:15][CH2:16]3)[C:6]=2[CH:24]=1.[ClH:26]

Participants

6

Reactant 2

HCID 313Hydrochloric AcidHCID 59850137HCID 59850137, compound

Product 2

HCID 313Hydrochloric AcidHCID 69122553HCID 69122553, compound

Reagents, catalysts & solvents 2

HCID 312751,4-DioxaneSolventHCID 21881112Ethyl ether methylene chlorideSolvent

Procedure

1,1-Dimethylethyl 4-(6-chloro-5-fluoro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinecarboxylate (D4) (0.460 mmol, 170 mg) was dissolved in dichloromethane-diethyl ether, and HCl (5 ml of a 4M solution in 1,4-dioxane) was added at room temperature; the mixture was shaken at room temperature overnight. Solvent was evaporated to afford the title compound, mono hydrochloride salt, complete conversion, M++H=270.

Workup

  1. customSolvent was evaporated

Sources & evidence

ORD record
ord-468b19f9b4ba4090ba9797a4767d473d
Source dataset
uspto-grants-2012_10
Patent number
US08288412B2

Reaction notes

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