HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Hydrochloric Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,1-Dimethylethyl 4-(6-chloro-5-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinecarboxylate | HCID 59850176 | — |
| Product | Hydrochloric Acid | HCID 313 | — |
| Product | 6-Chloro-5-methyl-1-(4-piperidinyl)-1,3-dihydro-2H-benzimidazol-2-one hydrochloride | HCID 69128188 | — |
Reaction Steps
1,1-Dimethylethyl 4-(6-chloro-5-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinecarboxylate (D8) (0.270 mmol, 100 mg) was treated with 8 ml of HCl (4M solution in 1,4-dioxane) at room temperature; the mixture was stirred at room temperature for 5 hours. Solvent was evaporated to afford the title compound, mono hydrochloride salt, 60 mg, 90%, M++H=266.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08288412B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-07b2542b3ae245448e4c238ea8de7b24 |
| Source note | uspto-grants-2012_10 |