Hydrochloric Acid → Hydrochloric Acid

HRID 2064127Notes

Reaction equation

HRID 2064127 reaction equation
[Cl:1][C:2]1[C:3]([CH3:25])=[CH:4][C:5]2[NH:9][C:8](=[O:10])[N:7]([CH:11]3[CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13][CH2:12]3)[C:6]=2[CH:24]=1.[ClH:26]>>[ClH:1].[Cl:1][C:2]1[C:3]([CH3:25])=[CH:4][C:5]2[NH:9][C:8](=[O:10])[N:7]([CH:11]3[CH2:12][CH2:13][NH:14][CH2:15][CH2:16]3)[C:6]=2[CH:24]=1.[ClH:26]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 598501761,1-Dimethylethyl 4-(6-chloro-5-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinecarboxylate

Product 2

HCID 313Hydrochloric AcidHCID 691281886-Chloro-5-methyl-1-(4-piperidinyl)-1,3-dihydro-2H-benzimidazol-2-one hydrochloride

Procedure

1,1-Dimethylethyl 4-(6-chloro-5-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinecarboxylate (D8) (0.270 mmol, 100 mg) was treated with 8 ml of HCl (4M solution in 1,4-dioxane) at room temperature; the mixture was stirred at room temperature for 5 hours. Solvent was evaporated to afford the title compound, mono hydrochloride salt, 60 mg, 90%, M++H=266.

Workup

  1. customSolvent was evaporated

Sources & evidence

ORD record
ord-07b2542b3ae245448e4c238ea8de7b24
Source dataset
uspto-grants-2012_10
Patent number
US08288412B2

Reaction notes

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