Hydrochloric Acid → Hydrochloric Acid

Participants

Reaction Steps

1,1-Dimethylethyl 4-[5-chloro-2-oxo-6-(trifluoromethyl)-2,3-dihydro-1H-benzimidazol-1-yl]-1-piperidinecarboxylate D12 (0.27 mmol, 115 mg) was treated with HCl (315 microliters of a 4M solution in 1,4-dioxane) at room temperature; the mixture was stirred at room temperature for 2.5 hours. Solvent was evaporated to afford the title compound, mono hydrochloride salt, 82 mg, 96%, M++H=320.

Provenance & Evidence