Hydrochloric Acid → Hydrochloric Acid

HRID 2064131Notes

Reaction equation

HRID 2064131 reaction equation
[Cl:1][C:2]1[C:24]([C:25]([F:28])([F:27])[F:26])=[CH:23][C:5]2[N:6]([CH:10]3[CH2:15][CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12][CH2:11]3)[C:7](=[O:9])[NH:8][C:4]=2[CH:3]=1.[ClH:29]>O1CCOCC1>[ClH:1].[Cl:1][C:2]1[C:24]([C:25]([F:26])([F:27])[F:28])=[CH:23][C:5]2[N:6]([CH:10]3[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]3)[C:7](=[O:9])[NH:8][C:4]=2[CH:3]=1.[ClH:29]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 59850175HCID 59850175, compound

Product 2

HCID 313Hydrochloric AcidHCID 69237227HCID 69237227, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

1,1-Dimethylethyl 4-[5-chloro-2-oxo-6-(trifluoromethyl)-2,3-dihydro-1H-benzimidazol-1-yl]-1-piperidinecarboxylate D12 (0.27 mmol, 115 mg) was treated with HCl (315 microliters of a 4M solution in 1,4-dioxane) at room temperature; the mixture was stirred at room temperature for 2.5 hours. Solvent was evaporated to afford the title compound, mono hydrochloride salt, 82 mg, 96%, M++H=320.

Workup

  1. customSolvent was evaporated

Sources & evidence

ORD record
ord-d512ad5bef2244c1a5b8975ccca94508
Source dataset
uspto-grants-2012_10
Patent number
US08288412B2

Reaction notes

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