反应详情

1,1-Dimethylethyl 4-(5-fluoro-6-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidine-carboxylate (D29) (0.68 mmol, 239 mg) in dichloromethane (5 mL) was treated under argon at room temperature with trifluoroacetic acid (1 mL) and allowed to stir for 1 h. The mixture was concentrated, treated with 10% Na2CO3 aqueous solution, extracted 3 times with ethyl acetate. Organics were combined, dried on MgSO4, and concentrated under vacuum to give the title compound (0.64 mmol, 160 mg, 94% yield). M+H=250.2.

1. concentrationThe mixture was concentrated
2. additiontreated with 10% Na2CO3 aqueous solution
3. extractionextracted 3 times with ethyl acetate
4. customdried on MgSO4
5. concentrationconcentrated under vacuum