Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 1,2-Dichloro-4-fluoro-5-nitrobenzene | HCID 533951 | — |
| Reactant | 1-(Oxan-4-yl)piperidin-4-amine dihydrochloride | HCID 45156751 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Diisopropylethylamine | HCID 81531 | — |
| Product | HCID 59850157 | HCID 59850157 | — |
Reaction Steps
4,5-Dichloro-2-fluoronitrobenzene (315 mg) was dissolved in dry dimethylformamide (10 ml) and diisopropylethylamine (0.85 ml), and 1-(tetrahydro-2H-pyran-4-yl)-4-piperidinamine dihydrochloride (D40) (450 mg) were added at room temperature. The mixture was stirred at 80° C. for 1 h, then cooled to room temperature and water and ethyl acetate added. The organic layer was dried over MgSO4, filtered and evaporated to give the title compound, 350 mg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08288412B2 |
|---|
| Source dataset | uspto-grants-2012_10 |
|---|
| ORD ID | ord-68b5e2bcf6354fbb9e70fe4e3dc3233a |
|---|
| Source note | uspto-grants-2012_10 |
|---|
