反应详情

A solution of 2-chloro-5-fluorophenol (1.5 g) in dichloromethane (50 ml) at 0° C. was treated with nitric acid (70%, 0.7 ml). The cooling bath was removed and after 15 min at room temperature the solution washed with water then dried over MgSO4, filtered and evaporated. The product was crystallised from diethyl ether to yield the title compound, 500 mg.

1. customThe cooling bath was removed and after 15 min at room temperature the solution
2. washwashed with water
3. dry with materialthen dried over MgSO4
4. filtrationfiltered
5. customevaporated
6. customThe product was crystallised from diethyl ether