Nitric Acid → 2-Chloro-5-fluoro-4-nitrophenol

HRID 2064146Notes

Reaction equation

HRID 2064146 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[OH:9].[N+:10]([O-])([OH:12])=[O:11]>ClCCl>[Cl:1][C:2]1[CH:7]=[C:6]([N+:10]([O-:12])=[O:11])[C:5]([F:8])=[CH:4][C:3]=1[OH:9]

Participants

4

Reactant 2

HCID 944Nitric AcidHCID 27245222-Chloro-5-fluorophenol

Product 1

HCID 596853292-Chloro-5-fluoro-4-nitrophenol

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 2-chloro-5-fluorophenol (1.5 g) in dichloromethane (50 ml) at 0° C. was treated with nitric acid (70%, 0.7 ml). The cooling bath was removed and after 15 min at room temperature the solution washed with water then dried over MgSO4, filtered and evaporated. The product was crystallised from diethyl ether to yield the title compound, 500 mg.

Workup

  1. customThe cooling bath was removed and after 15 min at room temperature the solution
  2. washwashed with water
  3. dry with materialthen dried over MgSO4
  4. filtrationfiltered
  5. customevaporated
  6. customThe product was crystallised from diethyl ether

Sources & evidence

ORD record
ord-defd8d2bb463425396da5a647411f390
Source dataset
uspto-grants-2012_10
Patent number
US08288412B2

Reaction notes

Loading…