HuagongsheHuagongshe Chemistry Print Report · For research reference only
Nitric Acid → 2-Chloro-5-fluoro-4-nitrophenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Nitric Acid | HCID 944 | — |
| Reactant | 2-Chloro-5-fluorophenol | HCID 2724522 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-Chloro-5-fluoro-4-nitrophenol | HCID 59685329 | — |
Reaction Steps
A solution of 2-chloro-5-fluorophenol (1.5 g) in dichloromethane (50 ml) at 0° C. was treated with nitric acid (70%, 0.7 ml). The cooling bath was removed and after 15 min at room temperature the solution washed with water then dried over MgSO4, filtered and evaporated. The product was crystallised from diethyl ether to yield the title compound, 500 mg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08288412B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-defd8d2bb463425396da5a647411f390 |
| Source note | uspto-grants-2012_10 |