Hydrochloric Acid → 6-Methoxy-5-chloro-1-(4-piperidinyl)-1,3-dihydro-2H-benzimidazol-2-one hydrochloride

HRID 2064155Notes

Reaction equation

HRID 2064155 reaction equation
[CH3:1][O:2][C:3]1[C:4]([Cl:26])=[CH:5][C:6]2[NH:10][C:9](=[O:11])[N:8]([CH:12]3[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]3)[C:7]=2[CH:25]=1.Cl>C(O)C>[ClH:26].[CH3:1][O:2][C:3]1[C:4]([Cl:26])=[CH:5][C:6]2[NH:10][C:9](=[O:11])[N:8]([CH:12]3[CH2:13][CH2:14][NH:15][CH2:16][CH2:17]3)[C:7]=2[CH:25]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 598502061,1-Dimethylethyl 4-(6-methoxy-5-chloro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinecarboxylate

Product 1

HCID 691284086-Methoxy-5-chloro-1-(4-piperidinyl)-1,3-dihydro-2H-benzimidazol-2-one hydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1,1-Dimethylethyl 4-(6-methoxy-5-chloro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinecarboxylate (D49) (35 mg) was dissolved in ethanol (1 ml) and HCl (4M in 1,4-dioxane, 1 ml) was added at room temperature. The mixture was stirred at room temperature for 4 h then evaporated to give the title compound, 30 mg.

Workup

  1. customthen evaporated

Sources & evidence

ORD record
ord-96fe46227fe342539a1d4135c86d4595
Source dataset
uspto-grants-2012_10
Patent number
US08288412B2

Reaction notes

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