Hydrochloric Acid → Hydrochloric Acid

Participants

Reaction Steps

1,1-Dimethylethyl 4-[6-methyl-2-oxo-5-(trifluoromethyl)-2,3-dihydro-1H-benzimidazol-1-yl]-1-piperidinecarboxylate (D59) (2.23 mmol, 900 mg) was treated with HCl (10 ml of a 4M solution in 1,4-dioxane) at room temperature; the mixture was stirred at room temperature overnight. Solvent was evaporated to afford the title compound, mono hydrochloride salt, complete conversion, M++H=300.

Provenance & Evidence