Hydrochloric Acid → Hydrochloric Acid

HRID 2064164Notes

Reaction equation

HRID 2064164 reaction equation
[CH3:1][C:2]1[C:3]([C:25]([F:28])([F:27])[F:26])=[CH:4][C:5]2[NH:9][C:8](=[O:10])[N:7]([CH:11]3[CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13][CH2:12]3)[C:6]=2[CH:24]=1.[ClH:29]>O1CCOCC1>[ClH:29].[CH3:1][C:2]1[C:3]([C:25]([F:27])([F:26])[F:28])=[CH:4][C:5]2[NH:9][C:8](=[O:10])[N:7]([CH:11]3[CH2:12][CH2:13][NH:14][CH2:15][CH2:16]3)[C:6]=2[CH:24]=1.[ClH:29]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 59850145HCID 59850145, compound

Product 2

HCID 313Hydrochloric AcidHCID 69171370HCID 69171370, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

1,1-Dimethylethyl 4-[6-methyl-2-oxo-5-(trifluoromethyl)-2,3-dihydro-1H-benzimidazol-1-yl]-1-piperidinecarboxylate (D59) (2.23 mmol, 900 mg) was treated with HCl (10 ml of a 4M solution in 1,4-dioxane) at room temperature; the mixture was stirred at room temperature overnight. Solvent was evaporated to afford the title compound, mono hydrochloride salt, complete conversion, M++H=300.

Workup

  1. customSolvent was evaporated

Sources & evidence

ORD record
ord-85721301ba9d4e54bed432b6ee29994a
Source dataset
uspto-grants-2012_10
Patent number
US08288412B2

Reaction notes

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