Water → 1,1-Dimethylethyl 4-[(4-trifluoromethyl-5-chloro-2-nitrophenyl)amino]-1-piperidinecarboxylate

https://huagongshe.com/reaction/2064165

Participants

Role	Name	HCID	Charge
Reactant	Water	HCID 962	—
Reactant	Ethyl Acetate	HCID 8857	—
Reactant	2,4-Dichloro-5-nitrobenzotrifluoride	HCID 621179	—
Reactant	4-Amino-1-Boc-piperidine	HCID 1268291	—
Solvent	Dimethylformamide	HCID 6228	—
Solvent	Diisopropylethylamine	HCID 81531	—
Product	1,1-Dimethylethyl 4-[(4-trifluoromethyl-5-chloro-2-nitrophenyl)amino]-1-piperidinecarboxylate	HCID 59850130	—

Reaction Conditions

Temperature	80 °C

Reaction Steps

1,5-Dichloro-2-nitro-4-(trifluoromethyl)benzene (5.5 g) was dissolved in dry dimethylformamide (50 ml) and diisopropylethylamine (5.1 ml), and 1,1-dimethylethyl 4-amino-1-piperidinecarboxylate (5.0 g) were added at room temperature. The mixture was stirred at 80° C. for 2.5 h, then water and ethyl acetate added. The organic layer was washed with water then brine, dried over MgSO4, filtered and evaporated, and the residue was crystallised from diethyl ether to afford the subtitle compound, 6.7 g.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08288412B2
Source dataset	uspto-grants-2012_10
ORD ID	ord-b1755e0605bd4f5b85622a551fa566c6
Source note	uspto-grants-2012_10