反应详情

温度

80 °C

1,5-Dichloro-2-nitro-4-(trifluoromethyl)benzene (5.5 g) was dissolved in dry dimethylformamide (50 ml) and diisopropylethylamine (5.1 ml), and 1,1-dimethylethyl 4-amino-1-piperidinecarboxylate (5.0 g) were added at room temperature. The mixture was stirred at 80° C. for 2.5 h, then water and ethyl acetate added. The organic layer was washed with water then brine, dried over MgSO4, filtered and evaporated, and the residue was crystallised from diethyl ether to afford the subtitle compound, 6.7 g.

1. washThe organic layer was washed with water
2. dry with materialbrine, dried over MgSO4
3. filtrationfiltered
4. customevaporated
5. customthe residue was crystallised from diethyl ether