HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 5-Trifluoromethyl-6-chloro-1-(4-piperidinyl)-1,3-dihydro-2H-benzimidazol-2-one hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,1-Dimethylethyl 4-(5-trifluoromethyl-6-chloro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinecarboxylate | HCID 59850214 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 5-Trifluoromethyl-6-chloro-1-(4-piperidinyl)-1,3-dihydro-2H-benzimidazol-2-one hydrochloride | HCID 69128764 | — |
Reaction Steps
1,1-Dimethylethyl 4-(5-trifluoromethyl-6-chloro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinecarboxylate (D63, 1.0 g) was dissolved in dichloromethane (10 ml) and HCl (4M in 1,4-dioxane, 2.5 ml) was added at room temperature. The mixture was stirred at room temperature for 4 h then evaporated to give the subtitle compound, 850 mg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08288412B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-629270c7e04b4919b0e63077427abee8 |
| Source note | uspto-grants-2012_10 |